Estrogen signaling prevents diet - induced hepatic insulin resistance 1 in male mice with obesity
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چکیده
Estrogen signaling prevents diet-induced hepatic insulin resistance 1 in male mice with obesity. 2 3 4 5 6 Lin Zhu , Melissa N. Martinez , Christopher H. Emfinger , Brian T. Palmisano , and 7 John M. Stafford * 8 9 1 Tennessee Valley Healthcare System, 2 Division of Diabetes, Endocrinology, & 10 Metabolism, Department of Internal Medicine, 3 Department of Molecular Physiology 11 and Biophysics, Vanderbilt University School of Medicine 12 13 14 15 16 17 18 * Address correspondence and request for reprints to: John M. Stafford, 7445D Medical 19 Research Building IV, Nashville, TN 37232-0475, phone (615) 936-6113, fax (615) 9362
منابع مشابه
Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with obesity.
The development of insulin resistance in the liver is a key event that drives dyslipidemia and predicts diabetes and cardiovascular risk with obesity. Clinical data show that estrogen signaling in males helps prevent adiposity and insulin resistance, which may be mediated through estrogen receptor-α (ERα). The tissues and pathways that mediate the benefits of estrogen signaling in males with ob...
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تاریخ انتشار 2014